Josephson effect test for triplet pairing symmetry

The critical current modulation and the spontaneous flux of the vortex states in corner Josephson junctions between Sr$_2$RuO$_4$ and a conventional s-wave superconductor are calculated as a function of the crystal orientation, and the magnetic field. For Sr$_2$RuO$_4$ we assume two nodeless p-wave pairing states. Also we use the nodal $f$-wave states $B_{1g}\times E_u$ and $B_{2g} \times E_u$, and one special p-wave state having line nodes. It is seen that the critical current depends solely on the topology of the gap.Comment: 22 pages, 12 figure

Zero-bias conductance peak splitting due to multiband effect in tunneling spectroscopy

We study how the multiplicity of the Fermi surface affects the zero-bias peak in conductance spectra of tunneling spectroscopy. As case studies, we consider models for organic superconductors $\kappa$-(BEDT-TTF)$_2$Cu(NCS)$_2$ and (TMTSF)$_2$ClO$_4$. We find that multiplicity of the Fermi surfaces can lead to a splitting of the zero-bias conductance peak (ZBCP). We propose that the presence/absence of the ZBCP splitting is used as a probe to distinguish the pairing symmetry in $\kappa$-(BEDT-TTF)$_2$Cu(NCS)$_2$.Comment: 7 pages, 7 figure

Rho GTPase function in flies: insights from a developmental and organismal perspective.

Morphogenesis is a key event in the development of a multicellular organism and is reliant on coordinated transcriptional and signal transduction events. To establish the segmented body plan that underlies much of metazoan development, individual cells and groups of cells must respond to exogenous signals with complex movements and shape changes. One class of proteins that plays a pivotal role in the interpretation of extracellular cues into cellular behavior is the Rho family of small GTPases. These molecular switches are essential components of a growing number of signaling pathways, many of which regulate actin cytoskeletal remodeling. Much of our understanding of Rho biology has come from work done in cell culture. More recently, the fruit fly Drosophila melanogaster has emerged as an excellent genetic system for the study of these proteins in a developmental and organismal context. Studies in flies have greatly enhanced our understanding of pathways involving Rho GTPases and their roles in development

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2–host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models. These mucins also inhibit infection of diverse respiratory viruses. This functional landscape of SARS-CoV-2 host factors provides a physiologically relevant starting point for new host-directed therapeutics and highlights airway mucins as a host defense mechanism

Construction and response of a highly granular scintillator-based electromagnetic calorimeter

A highly granular electromagnetic calorimeter with scintillator strip readout is being developed for future linear collider experiments. A prototype of 21.5 푋0 depth and 180 × 180 mm2 transverse dimensions was constructed, consisting of 2160 individually read out 10 × 45 × 3 mm3 scintillator strips. This prototype was tested using electrons of 2–32 GeV at the Fermilab Test Beam Facility in 2009. Deviations from linear energy response were less than 1.1%, and the intrinsic energy resolution was determined to be (12.5±0.1(stat.)±0.4(syst.))%∕√퐸[GeV]⊕(1.2± 0.1(stat.)+0.6−0.7(syst.))%, where the uncertainties correspond to statistical and systematic sources, respectively

Export from Pericentriolar Endocytic Recycling Compartment to Cell Surface Depends on Stable, Detyrosinated (Glu) Microtubules and Kinesin

A significant fraction of internalized transferrin (Tf) concentrates in the endocytic recycling compartment (ERC), which is near the microtubule-organizing center in many cell types. Tf then recycles back to the cell surface. The mechanisms controlling the localization, morphology, and function of the ERC are not fully understood. We examined the relationship of Tf trafficking with microtubules (MTs), specifically the subset of stable, detyrosinated Glu MTs. We found some correlation between the level of stable Glu MTs and the distribution of the ERC; in cells with low levels of Glu MTs concentrated near to the centriole, the ERC was often tightly clustered, whereas in cells with higher levels of Glu MTs throughout the cell, the ERC was more dispersed. The clustered ERC in Chinese hamster ovary cells became dispersed when the level of Glu MTs was increased with taxol treatment. Furthermore, in a temperature-sensitive Chinese hamster ovary cell line (B104-5), the cells had more Glu MTs when the ERC became dispersed at elevated temperature. Microinjecting purified anti-Glu tubulin antibody into B104-5 cells at elevated temperature induced the redistribution of the ERC to a tight cluster. Microinjection of anti-Glu tubulin antibody slowed recycling of Tf to the cell surface without affecting Tf internalization or delivery to the ERC. Similar inhibition of Tf recycling was caused by microinjecting anti-kinesin antibody. These results suggest that stable Glu MTs and kinesin play a role in the organization of the ERC and in facilitating movement of vesicles from the ERC to the cell surface